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Sunday, 05th February 2012

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  • »    2012-02-08 -> 2012-02-10   
    XXIX Course on Gineacological Laparoscopic Surgery

  • »    2012-02-23 -> 2012-02-25   
    XI Course On Advanced Thoracoscopic Surgery

  • »    2012-02-27 -> 2012-02-28   
    9th Course on Basic Endoluminal and Interventional Radiology Techniques in Veterinary Medicine

  • »    2012-03-09 -> 2012-03-09   
    III Curso Básico de Reproducción Asistida en Manejo y Extracción de Gametos y Embriones de Ratón

  • »    2012-03-12 -> 2012-03-14   
    5th International Intensive Training Course for Transanal Endoscopic Microsurgery (TEM)

  • »    2012-03-22 -> 2012-03-23   
    XI Course on Endourology

  • »    2012-03-27 -> 2012-03-29   
    Papel del Farmacéutico en Urgencias: primeros auxilios

  • »    2012-03-29 -> 2012-03-31   
    VII Course on thoracic endosurgery in childhood

  • »    2012-04-11 -> 2012-04-13   
    XIII CURSO PRÁCTICO SOBRE TRATAMIENTOS DE DEPURACIÓN EXTRACORPÓREA

  • »    2012-04-13 -> 2012-04-13   
    V Curso Práctico de Manejo de Stent Metálicos en Gastroenterología

  • »    2012-04-16 -> 2012-05-07   
    XV Course on Laparoscopic Radical Prostatectomy

  • »    2012-04-19 -> 2012-04-20   
    III Course of Advance Gynaecological Laparoscopy

  • »    2012-04-19 -> 2012-04-21   
    XIV Theoretical and Practical Course on Microsurgery: Vessels and Nerves

  • »    2012-04-19 -> 2012-04-21   
    I Practium ASEBIR de Embriología Clínica

  • »    2012-05-03 -> 2012-05-05   
    III Course on eyelid and ocular surface surgery in veterinary

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Pharmacological Trials and Health Products
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Toxicology

 

Standardized toxicological studies in support of the pharmaceutical industry and medical devices industry are developed, which are carried out in conjunction with global regulatory directives.

 

Species:

 

The usual strains for single-dose studies and repeated administration of drugs include Wistar rats, NMRI mice and Beagle dogs. We have, at the request of the client, other breeds and species of rodents. As a non-rodent species alternative, we use Large-white pigs, sheep and rabbits.

 

Routes of administration:

 

These include oral application (probing, diet and capsules), dermal or intraperitoneal, intravenous injection (bolus or infusion), intramuscular or subcutaneous, and inhalation.

 

The most common studies are:

  • Single dose.
  • Maximum tolerated dose.
  • Local tolerance.
  • Repeated Administration, 2, 4, 13, 26, 39 or 52 weeks.

Repeated administration studies can be designed with recovery groups and normally include toxicokinetic assessment.

 

Pharmacology Security

 

The JUMISC offers all studies and trials of pharmaceuticals and medical devices before the first administration or application to volunteers in Phase I trials:

  • Central nervous system (Screening Test Irwin modified battery of tests observation from a functional point of view).
  • Cardiovascular system (telemetric monitoring of animals).
  • Respiratory system.

The customer can benefit from a series of complementary studies to evaluate pharmacological properties in all the major anatomical and physiological systems.

 

Pharmacokinetic studies

 

Made up of several regulatory requirements for the development of drugs, these are beginning to become an integral part of advance in drug discovery.

 

Species: Dogs, rabbits, dogs, pigs, sheep.

Roads: Oral, intraperitoneal, intravenous, subcutaneous, inhalation, intratracheal.
Simple and multiple administration. 

 

Obtaining blood samples: up to 8 samples of blood from a rat, handling the animals without causing them stress.

Bio-analytics.

Rapid development of the method: High processing samples.
HPLC/MS/MS, GC/MS, CE, RT-PCR

 

Pharmacokinetic analysis is done using non-linear regression software WinNonlin Professional v. 4.1.

 

Last Updated on Friday, 04 September 2009 12:57
 
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